Research School in Systems Biology
The Research School for Systems Biology (RS-SysBio) was established at the Norwegian University of Life Sciences (UMB) in December 2006.
The primary goal of the research school is to establish a fruitful scientific environment for the the PhD-students working in systems biology on campus. Further, the research school wants to be a meeting place for researchers, PhD-students and MSc-students interested in systems biology at UMB and the surrounding research institutions at Campus Ås.
Do you want to be on the RS-SysBio mailing list and be informed by upcoming activities? Send an email to Klas.Pettersen@gmail.com.
12.10.2012: Workshop on genotype-phenotype modelling
From sequence to consequence: Theoretical and experimental studies of how biological mechanisms shape the genotype-phenotype map.
Please see http://www.cigene.no/ for more information. Deadline for registration: 3rd October.
Background: The main methods for analyzing the relation between genotype and phenotypes, such as association studies, are based on linear models. These models were introduced long before the establishment of molecular biology, and need to be complemented by models emphasizing how genes act and interact. The emerging branch of genetics called "systems genetics" covers a range of network methods to describe the relationship between genotypes and layers of phenotypes, ranging from the transcriptome and proteome up to higher-level physiological traits. The methods employed include multivariate methods for discovering correlation networks in –omics data, coarse-grained methods such as Bayesian networks and structural equations for learning causal networks, and non-linear dynamic models that explicitly represent process rates as a function of state. This workshop is intended to promote the exchange of perspectives and different angles of approach in systems genetics, and we believe it will stimulate novel work for everybody attending. The workshop is open for master and PhD students, postdocs and researchers.
21.10.2012: Talk by Steven Niederer, Division of Imaging Sciences and Biomedical Engineering at King's College London
- Title: Modelling Cardiac Calcium Dynamics in the SERCA KO Mouse
- Time: 10:00-11:00
- Location: UMB, Dept of Mathematical Sciences and Technology (IMT), Room TF141
In the cardiac myocyte the Ca2+ transient signals contraction with each beat. Ca2+ dynamics are regulated by the movement of ions across the cell membrane and within the cell. Central to this regulation is the uptake of Ca2+ from the cytosol into the sarcoplasmic reticulum. In SERCA KO mice, the serca2 gene is excised and protein expression decays over 7 weeks. Over this period the sarcoplasmic reticulum Ca2+ dynamics breakdown and compensatory pathways are up-regulated to maintain Ca2+ regulation. To unravel the effects of the compensatory mechanisms biophysical models of cardiac myocytes from control mice and from mice 4 weeks and 7 weeks post Serca2 excision were developed. The models capture the progression of the compensatory mechanisms and provide a quantitative description of the mechanisms underlying the progression of these mice towards a heart failure phenotype.
Further information: www