Research School in Systems Biology
The Research School for Systems Biology (RS-SysBio) was established at the Norwegian University of Life Sciences (UMB) in December 2006.
The primary goal of the research school is to establish a fruitful scientific environment for the the PhD-students working in systems biology on campus. Further, the research school wants to be a meeting place for researchers, PhD-students and MSc-students interested in systems biology at UMB and the surrounding research institutions at Campus Ås.
Do you want to be on the RS-SysBio mailing list and be informed by upcoming activities? Send an email to Klas.Pettersen@gmail.com.
Upcoming events
21.10.2011: Talk by Steven Niederer, Division of Imaging Sciences and Biomedical Engineering at King's College London
- Title: Modelling Cardiac Calcium Dynamics in the SERCA KO Mouse
- Time: 10:00-11:00
- Location: UMB, Dept of Mathematical Sciences and Technology (IMT), Room TF141
In the cardiac myocyte the Ca2+ transient signals contraction with each beat. Ca2+ dynamics are regulated by the movement of ions across the cell membrane and within the cell. Central to this regulation is the uptake of Ca2+ from the cytosol into the sarcoplasmic reticulum. In SERCA KO mice, the serca2 gene is excised and protein expression decays over 7 weeks. Over this period the sarcoplasmic reticulum Ca2+ dynamics breakdown and compensatory pathways are up-regulated to maintain Ca2+ regulation. To unravel the effects of the compensatory mechanisms biophysical models of cardiac myocytes from control mice and from mice 4 weeks and 7 weeks post Serca2 excision were developed. The models capture the progression of the compensatory mechanisms and provide a quantitative description of the mechanisms underlying the progression of these mice towards a heart failure phenotype.
Further information: www
Organisation of research school
Leader: Prof. Gaute T. Einevoll ( Gaute.Einevoll@umb.no)
Coordinator and secretary: Dr. Klas Pettersen ( Klas.Pettersen@gmail.com)
